Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects approximately 11 million people in Latin America. The involvement of the host's immune response on the development of severe forms of Chagas disease has not been fully elucidated. Studies on the immune re...

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Main Authors:	Fiuza, Jacqueline Araújo, Fujiwara, Ricardo Toshio, Gomes, Juliana Assis Silva, Rocha, Manoel Otávio das Costa, Chaves, Ana Thereza, de Araújo, Fernanda Fortes, Fares, Rafaelle Christine Gomes, Teixeira-Carvalho, Andrea, Martins-Filho, Olindo de Assis, Cançado, Guilherme Grossi Lopes, Correa-Oliveira, Rodrigo
Format:	Online
Language:	English
Published:	Public Library of Science 2009
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729721/

id	pubmed-2729721
recordtype	oai_dc
spelling	pubmed-27297212009-09-09 Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease Fiuza, Jacqueline Araújo Fujiwara, Ricardo Toshio Gomes, Juliana Assis Silva Rocha, Manoel Otávio das Costa Chaves, Ana Thereza de Araújo, Fernanda Fortes Fares, Rafaelle Christine Gomes Teixeira-Carvalho, Andrea Martins-Filho, Olindo de Assis Cançado, Guilherme Grossi Lopes Correa-Oliveira, Rodrigo Research Article Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects approximately 11 million people in Latin America. The involvement of the host's immune response on the development of severe forms of Chagas disease has not been fully elucidated. Studies on the immune response against T. cruzi infection show that the immunoregulatory mechanisms are necessary to prevent the deleterious effect of excessive immune response stimulation and consequently the fatal outcome of the disease. A recall response against parasite antigens observed in in vitro peripheral blood cell culture clearly demonstrates that memory response is generated during infection. Memory T cells are heterogeneous and differ in both the ability to migrate and exert their effector function. This heterogeneity is reflected in the definition of central (TCM) and effector memory (TEM) T cells. Our results suggest that a balance between regulatory and effectors T cells may be important for the progression and development of the disease. Furthermore, the high percentage of central memory CD4+ T cells in indeterminate patients after stimulation suggests that these cells may modulate host's inflammatory response by controlling cell migration to tissues and their effector role during chronic phase of the disease. Public Library of Science 2009-09-09 /pmc/articles/PMC2729721/ /pubmed/19742301 http://dx.doi.org/10.1371/journal.pntd.0000512 Text en Fiuza et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fiuza, Jacqueline Araújo Fujiwara, Ricardo Toshio Gomes, Juliana Assis Silva Rocha, Manoel Otávio das Costa Chaves, Ana Thereza de Araújo, Fernanda Fortes Fares, Rafaelle Christine Gomes Teixeira-Carvalho, Andrea Martins-Filho, Olindo de Assis Cançado, Guilherme Grossi Lopes Correa-Oliveira, Rodrigo
spellingShingle	Fiuza, Jacqueline Araújo Fujiwara, Ricardo Toshio Gomes, Juliana Assis Silva Rocha, Manoel Otávio das Costa Chaves, Ana Thereza de Araújo, Fernanda Fortes Fares, Rafaelle Christine Gomes Teixeira-Carvalho, Andrea Martins-Filho, Olindo de Assis Cançado, Guilherme Grossi Lopes Correa-Oliveira, Rodrigo Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease
author_facet	Fiuza, Jacqueline Araújo Fujiwara, Ricardo Toshio Gomes, Juliana Assis Silva Rocha, Manoel Otávio das Costa Chaves, Ana Thereza de Araújo, Fernanda Fortes Fares, Rafaelle Christine Gomes Teixeira-Carvalho, Andrea Martins-Filho, Olindo de Assis Cançado, Guilherme Grossi Lopes Correa-Oliveira, Rodrigo
author_sort	Fiuza, Jacqueline Araújo
title	Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease
title_short	Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease
title_full	Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease
title_fullStr	Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease
title_full_unstemmed	Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease
title_sort	profile of central and effector memory t cells in the progression of chronic human chagas disease
description	Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects approximately 11 million people in Latin America. The involvement of the host's immune response on the development of severe forms of Chagas disease has not been fully elucidated. Studies on the immune response against T. cruzi infection show that the immunoregulatory mechanisms are necessary to prevent the deleterious effect of excessive immune response stimulation and consequently the fatal outcome of the disease. A recall response against parasite antigens observed in in vitro peripheral blood cell culture clearly demonstrates that memory response is generated during infection. Memory T cells are heterogeneous and differ in both the ability to migrate and exert their effector function. This heterogeneity is reflected in the definition of central (TCM) and effector memory (TEM) T cells. Our results suggest that a balance between regulatory and effectors T cells may be important for the progression and development of the disease. Furthermore, the high percentage of central memory CD4+ T cells in indeterminate patients after stimulation suggests that these cells may modulate host's inflammatory response by controlling cell migration to tissues and their effector role during chronic phase of the disease.
publisher	Public Library of Science
publishDate	2009
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729721/
_version_	1611442339518087168

Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease

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