Identification of a Domain which Affects Kinetics and Antagonistic Potency of Clozapine at 5-HT3 Receptors

Identification of a Domain which Affects Kinetics and Antagonistic Potency of Clozapine at 5-HT3 Receptors

The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT3 receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT3 receptors of various species. However, the structural requirements of the respective binding site for cloz...

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Bibliographic Details
Main Authors: Rammes, Gerhard, Hosp, Christine, Eisensamer, Brigitte, Tanasic, Sascha, Nothdurfter, Caroline, Zieglgänsberger, Walter, Rupprecht, Rainer
Format: Online
Language:English
Published: Public Library of Science 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725292/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725292/

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