Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle
Dysregulation of the mammalian target of rapamycin (mTOR) kinase pathway is centrally involved in a wide variety of cancers and human genetic diseases. In mammalian cells, mTOR is part of two different kinase complexes: mTORC1 composed of mTOR, raptor and mLST8, and mTORC2 containing mTOR, rictor, s...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722991/ |