Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The ma...
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| Format: | Online |
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Dove Medical Press
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721377/ |
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pubmed-2721377 |
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pubmed-27213772009-08-25 Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells Prakash, Satya Malgorzata Urbanska, Aleksandra Review There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The main objective of these oral therapy procedures is to deliver live cells not only to treat diseases like colorectal cancer, inflammatory bowel disease, and other GI tract diseases like intestinal obstruction and gastritis, but also to deliver therapeutic molecules for overall therapy in various diseases such as renal failure, coronary heart disease, hypertension, and others. This review provides a comprehensive summary of recent advancement in colon targeted live bacterial cell biotherapeutics. Current status of bacterial cell therapy, principles of artificial cells and its potentials in oral delivery of live bacterial cell biotherapeutics for clinical applications as well as biotherapeutic future perspectives are also discussed in our review. Dove Medical Press 2008-09 2008-09 /pmc/articles/PMC2721377/ /pubmed/19707368 Text en © 2008 Prakash and Urbanska, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Prakash, Satya Malgorzata Urbanska, Aleksandra |
| spellingShingle |
Prakash, Satya Malgorzata Urbanska, Aleksandra Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| author_facet |
Prakash, Satya Malgorzata Urbanska, Aleksandra |
| author_sort |
Prakash, Satya |
| title |
Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| title_short |
Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| title_full |
Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| title_fullStr |
Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| title_full_unstemmed |
Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| title_sort |
colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells |
| description |
There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The main objective of these oral therapy procedures is to deliver live cells not only to treat diseases like colorectal cancer, inflammatory bowel disease, and other GI tract diseases like intestinal obstruction and gastritis, but also to deliver therapeutic molecules for overall therapy in various diseases such as renal failure, coronary heart disease, hypertension, and others. This review provides a comprehensive summary of recent advancement in colon targeted live bacterial cell biotherapeutics. Current status of bacterial cell therapy, principles of artificial cells and its potentials in oral delivery of live bacterial cell biotherapeutics for clinical applications as well as biotherapeutic future perspectives are also discussed in our review. |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721377/ |
| _version_ |
1611440781893042176 |