Cetuximab in the management of colorectal cancer
Cetuximab, a chimeric IgG1 monoclonal antibody that targets the ligand-binding domain of the epidermal growth factor receptor (EGFR), is active in metastatic colorectal cancer (mCRC). As an IgG1 antibody, cetuximab may exert its antitumor efficacy through both EGFR antagonism and antibody-dependent...
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| Format: | Online |
| Language: | English |
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Dove Medical Press
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721306/ |