Tumor suppressor gene E-cadherin and its role in normal and malignant cells
E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin...
| Main Author: | |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2003
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270068/ |
| id |
pubmed-270068 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-2700682003-11-21 Tumor suppressor gene E-cadherin and its role in normal and malignant cells Pećina-Šlaus, Nives Review E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products. BioMed Central 2003-10-14 /pmc/articles/PMC270068/ /pubmed/14613514 http://dx.doi.org/10.1186/1475-2867-3-17 Text en Copyright © 2003 Pećina-Šlaus; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Pećina-Šlaus, Nives |
| spellingShingle |
Pećina-Šlaus, Nives Tumor suppressor gene E-cadherin and its role in normal and malignant cells |
| author_facet |
Pećina-Šlaus, Nives |
| author_sort |
Pećina-Šlaus, Nives |
| title |
Tumor suppressor gene E-cadherin and its role in normal and malignant cells |
| title_short |
Tumor suppressor gene E-cadherin and its role in normal and malignant cells |
| title_full |
Tumor suppressor gene E-cadherin and its role in normal and malignant cells |
| title_fullStr |
Tumor suppressor gene E-cadherin and its role in normal and malignant cells |
| title_full_unstemmed |
Tumor suppressor gene E-cadherin and its role in normal and malignant cells |
| title_sort |
tumor suppressor gene e-cadherin and its role in normal and malignant cells |
| description |
E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products. |
| publisher |
BioMed Central |
| publishDate |
2003 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270068/ |
| _version_ |
1611367568705060864 |