Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

The cellular pathways involved in maintaining genome stability halt cell cycle progression in the presence of DNA damage or incomplete replication. Proteins required for this pathway include Rad17, Rad9, Hus1, Rad1, and Rfc-2, Rfc-3, Rfc-4, and Rfc-5. The heteropentamer replication factor C (RFC) lo...

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Bibliographic Details
Main Authors: Ellison, Viola, Stillman, Bruce
Format: Online
Language:English
Published: Public Library of Science 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC261875/