Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study.
5,160 non-hysterectomised women aged 44-100 years completed a health survey questionnaire as part of a longitudinal study of a southern California retirement community begun in June 1981. As of 1 January 1987, 50 incident cancers of the endometrium had occurred among these women, who had contributed...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1989
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247072/ |
| id |
pubmed-2247072 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-22470722009-09-10 Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. Paganini-Hill, A. Ross, R. K. Henderson, B. E. Research Article 5,160 non-hysterectomised women aged 44-100 years completed a health survey questionnaire as part of a longitudinal study of a southern California retirement community begun in June 1981. As of 1 January 1987, 50 incident cancers of the endometrium had occurred among these women, who had contributed 23,786 years of follow-up. Women who had used oestrogen replacement therapy had a relative risk of endometrial cancer of 10 compared to women who had never used oestrogens (P less than 0.0001). Risk increased with increasing duration of use (chi 2 test for trend = 50.60, P less than 0.0001); women who had used oestrogens for 15 or more years had a relative risk of 20 (95% C.I. = 7.2, 54) compared to non-users. While current and recent users (i.e. those who had used oestrogen within one year of the initial survey) had the greatest risk (RR = 25, 95% C.I. = 9.2, 69), women who had last used oestrogens 15 or more years ago still had a significantly increased risk (RR = 5.8, 95% C.I. = 2.0, 17). No other variable studied had a major effect on risk, except smoking. Women who smoked at the time of menopause had a significantly reduced risk of disease (RR = 0.38, P = 0.005), which was essentially unchanged after adjustment for oestrogen use. Nature Publishing Group 1989-03 /pmc/articles/PMC2247072/ /pubmed/2930713 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Paganini-Hill, A. Ross, R. K. Henderson, B. E. |
| spellingShingle |
Paganini-Hill, A. Ross, R. K. Henderson, B. E. Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| author_facet |
Paganini-Hill, A. Ross, R. K. Henderson, B. E. |
| author_sort |
Paganini-Hill, A. |
| title |
Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| title_short |
Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| title_full |
Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| title_fullStr |
Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| title_full_unstemmed |
Endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| title_sort |
endometrial cancer and patterns of use of oestrogen replacement therapy: a cohort study. |
| description |
5,160 non-hysterectomised women aged 44-100 years completed a health survey questionnaire as part of a longitudinal study of a southern California retirement community begun in June 1981. As of 1 January 1987, 50 incident cancers of the endometrium had occurred among these women, who had contributed 23,786 years of follow-up. Women who had used oestrogen replacement therapy had a relative risk of endometrial cancer of 10 compared to women who had never used oestrogens (P less than 0.0001). Risk increased with increasing duration of use (chi 2 test for trend = 50.60, P less than 0.0001); women who had used oestrogens for 15 or more years had a relative risk of 20 (95% C.I. = 7.2, 54) compared to non-users. While current and recent users (i.e. those who had used oestrogen within one year of the initial survey) had the greatest risk (RR = 25, 95% C.I. = 9.2, 69), women who had last used oestrogens 15 or more years ago still had a significantly increased risk (RR = 5.8, 95% C.I. = 2.0, 17). No other variable studied had a major effect on risk, except smoking. Women who smoked at the time of menopause had a significantly reduced risk of disease (RR = 0.38, P = 0.005), which was essentially unchanged after adjustment for oestrogen use. |
| publisher |
Nature Publishing Group |
| publishDate |
1989 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247072/ |
| _version_ |
1611439849332539392 |