HLA expression in human hepatocellular carcinoma.
This study examines the expression of MHC class I and II antigens and their related invariant chains in 70 cases of human hepatocellular carcinoma (HCC), using monoclonal (Mabs) and polyclonal antibodies. In comparison with normal hepatocytes, the majority (94.3%) of HCCs show enhancement or acquisi...
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| Format: | Online |
| Language: | English |
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Nature Publishing Group
1988
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246568/ |
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pubmed-2246568 |
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oai_dc |
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pubmed-22465682009-09-10 HLA expression in human hepatocellular carcinoma. Paterson, A. C. Sciot, R. Kew, M. C. Callea, F. Dusheiko, G. M. Desmet, V. J. Research Article This study examines the expression of MHC class I and II antigens and their related invariant chains in 70 cases of human hepatocellular carcinoma (HCC), using monoclonal (Mabs) and polyclonal antibodies. In comparison with normal hepatocytes, the majority (94.3%) of HCCs show enhancement or acquisition of HLA-A, B, C in either a cytoplasmic or membranous distribution, with staining being uniformly distributed throughout the specimen. HLA-A, B, C was accompanied by beta 2-microglobulin expression in all but two cases. Although 44.9% of specimens showed HLA-DR expression, positively staining tumour cells were often sparse and heterogeneously distributed. By contrast, the invariant (I) chain, present in 47.1% of cases, was frequently intensively stained and extensive in distribution. HLA-DR staining was usually cytoplasmic although two cases showed faint membranous enhancement. In addition to HLA-DR and I-chain, two cases also showed HLA-DQ staining. Display of MHC antigens was not related to tumour differentiation or size of the lesion (resected vs. advanced tumours). It is possible that the acquisition of class I antigens by the majority of HCCs may influence tumour behaviour. Nature Publishing Group 1988-04 /pmc/articles/PMC2246568/ /pubmed/2839219 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Paterson, A. C. Sciot, R. Kew, M. C. Callea, F. Dusheiko, G. M. Desmet, V. J. |
| spellingShingle |
Paterson, A. C. Sciot, R. Kew, M. C. Callea, F. Dusheiko, G. M. Desmet, V. J. HLA expression in human hepatocellular carcinoma. |
| author_facet |
Paterson, A. C. Sciot, R. Kew, M. C. Callea, F. Dusheiko, G. M. Desmet, V. J. |
| author_sort |
Paterson, A. C. |
| title |
HLA expression in human hepatocellular carcinoma. |
| title_short |
HLA expression in human hepatocellular carcinoma. |
| title_full |
HLA expression in human hepatocellular carcinoma. |
| title_fullStr |
HLA expression in human hepatocellular carcinoma. |
| title_full_unstemmed |
HLA expression in human hepatocellular carcinoma. |
| title_sort |
hla expression in human hepatocellular carcinoma. |
| description |
This study examines the expression of MHC class I and II antigens and their related invariant chains in 70 cases of human hepatocellular carcinoma (HCC), using monoclonal (Mabs) and polyclonal antibodies. In comparison with normal hepatocytes, the majority (94.3%) of HCCs show enhancement or acquisition of HLA-A, B, C in either a cytoplasmic or membranous distribution, with staining being uniformly distributed throughout the specimen. HLA-A, B, C was accompanied by beta 2-microglobulin expression in all but two cases. Although 44.9% of specimens showed HLA-DR expression, positively staining tumour cells were often sparse and heterogeneously distributed. By contrast, the invariant (I) chain, present in 47.1% of cases, was frequently intensively stained and extensive in distribution. HLA-DR staining was usually cytoplasmic although two cases showed faint membranous enhancement. In addition to HLA-DR and I-chain, two cases also showed HLA-DQ staining. Display of MHC antigens was not related to tumour differentiation or size of the lesion (resected vs. advanced tumours). It is possible that the acquisition of class I antigens by the majority of HCCs may influence tumour behaviour. |
| publisher |
Nature Publishing Group |
| publishDate |
1988 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246568/ |
| _version_ |
1611439585207779328 |