G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
Rigorous quality control steps, termed checkpoints, tightly regulate progression through the cell cycle. DNA-damaging chemotherapy and radiation activate functional cellular checkpoints. These checkpoints can facilitate DNA repair and promote cell death in unrepaired cells. There are at least three...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243162/ |