Greglist: a database listing potential G-quadruplex regulated genes
The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression. Indeed, it has been demonstrated that the G-quadruplex for...
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| Format: | Online |
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Oxford University Press
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238908/ |
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pubmed-22389082008-02-12 Greglist: a database listing potential G-quadruplex regulated genes Zhang, Ren Lin, Yan Zhang, Chun-Ting Articles The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression. Indeed, it has been demonstrated that the G-quadruplex formed in the c-MYC promoter suppresses its transcriptional activity. Recent studies suggest that G-quadruplex motifs (GQMs) are enriched in human gene promoters. To facilitate the research of G-quadruplex, we have constructed Greglist, a database listing potentially G-quadruplex regulated genes. Greglist harbors genes that contain promoter GQMs from genomes of various species, including humans, mice, rats and chickens. Many important genes are found to contain previously unreported promoter GQMs, such as ATM, BAD, AKT1, LEPR, UCP1, APOE, DKK1, WT1, WEE1, WNT1 and CLOCK. Furthermore, we find that not only protein coding genes, 126 human microRNAs also contain promoter GQMs. Greglist therefore provides candidates for further studying G-quadruplex functions and is freely available at http://tubic.tju.edu.cn/greglist. Oxford University Press 2008-01 2007-10-04 /pmc/articles/PMC2238908/ /pubmed/17916572 http://dx.doi.org/10.1093/nar/gkm787 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhang, Ren Lin, Yan Zhang, Chun-Ting |
| spellingShingle |
Zhang, Ren Lin, Yan Zhang, Chun-Ting Greglist: a database listing potential G-quadruplex regulated genes |
| author_facet |
Zhang, Ren Lin, Yan Zhang, Chun-Ting |
| author_sort |
Zhang, Ren |
| title |
Greglist: a database listing potential G-quadruplex regulated genes |
| title_short |
Greglist: a database listing potential G-quadruplex regulated genes |
| title_full |
Greglist: a database listing potential G-quadruplex regulated genes |
| title_fullStr |
Greglist: a database listing potential G-quadruplex regulated genes |
| title_full_unstemmed |
Greglist: a database listing potential G-quadruplex regulated genes |
| title_sort |
greglist: a database listing potential g-quadruplex regulated genes |
| description |
The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression. Indeed, it has been demonstrated that the G-quadruplex formed in the c-MYC promoter suppresses its transcriptional activity. Recent studies suggest that G-quadruplex motifs (GQMs) are enriched in human gene promoters. To facilitate the research of G-quadruplex, we have constructed Greglist, a database listing potentially G-quadruplex regulated genes. Greglist harbors genes that contain promoter GQMs from genomes of various species, including humans, mice, rats and chickens. Many important genes are found to contain previously unreported promoter GQMs, such as ATM, BAD, AKT1, LEPR, UCP1, APOE, DKK1, WT1, WEE1, WNT1 and CLOCK. Furthermore, we find that not only protein coding genes, 126 human microRNAs also contain promoter GQMs. Greglist therefore provides candidates for further studying G-quadruplex functions and is freely available at http://tubic.tju.edu.cn/greglist. |
| publisher |
Oxford University Press |
| publishDate |
2008 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238908/ |
| _version_ |
1611438798385709056 |