Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites

Mutational analyses have suggested that BK channels are regulated by three distinct divalent cation-dependent regulatory mechanisms arising from the cytosolic COOH terminus of the pore-forming α subunit. Two mechanisms account for physiological regulation of BK channels by μM Ca2+. The third may med...

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Bibliographic Details
Main Authors: Zeng, Xu-Hui, Xia, Xiao-Ming, Lingle, Christopher J.
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234011/