Identification of the Ca2+ Blocking Site of Acid-sensing Ion Channel (ASIC) 1: Implications for Channel Gating
Acid-sensing ion channels ASIC1a and ASIC1b are ligand-gated ion channels that are activated by H+ in the physiological range of pH. The apparent affinity for H+ of ASIC1a and 1b is modulated by extracellular Ca2+ through a competition between Ca2+ and H+. Here we show that, in addition to modulatin...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233906/ |