Kinetics of Inward-Rectifier K+ Channel Block by Quaternary Alkylammonium Ions: Dimension and Properties of the Inner Pore
We examined block of two inward-rectifier K+ channels, IRK1 and ROMK1, by a series of intracellular symmetric quaternary alkylammonium ions (QAs) whose side chains contain one to five methylene groups. As shown previously, the ROMK1 channels bind larger QAs with higher affinity. In contrast, the IRK...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2001
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233664/ |