Ser165 in the Second Transmembrane Region of the Kir2.1 Channel Determines its Susceptibility to Blockade by Intracellular Mg2+
The strong inward rectification of Kir2.1 currents is reportedly due to blockade of the outward current by cytoplasmic magnesium (Mg2+ i) and polyamines, and is known to be determined in part by three negatively charged amino acid residues: Asp172, Glu224, and Glu299 (D172, E224, E299). Our aim was...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2002
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229556/ |