Light and dark active phosphodiesterase regulation in salamander rods

We studied the activation of 3',5'-cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) by using a cell-permeant enzyme inhibitor. Rods of Ambystoma tigrinum held in a suction electrode were jumped into a stream of 3-isobutyl-1-methylxanthine (IBMX), 0.01-1 mM. Initial transient l...

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Bibliographic Details
Format: Online
Language:English
Published: The Rockefeller University Press 1991
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229065/