Cocaine-induced closures of single batrachotoxin-activated Na+ channels in planar lipid bilayers

Batrachotoxin (BTX)-activated Na+ channels from rabbit skeletal muscle were incorporated into planar lipid bilayers. These channels appear to open most of the time at voltages greater than -60 mV. Local anesthetics, including QX-314, bupivacaine, and cocaine when applied internally, induce different...

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Bibliographic Details
Format: Online
Language:English
Published: The Rockefeller University Press 1988
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228921/