Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX.
Photodynamic therapy (PDT) may cause tumour cell destruction by direct toxicity or by inducing cellular hypoxia as a result of microcirculatory shutdown. Aminolaevulinic acid (ALA) causes cellular accumulation of protoporphyrin IX (PPIX) in cells exposed to it in excess. PPIX can be used as a photos...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1997
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228050/ |