Absence of p21 expression is associated with abnormal p53 in human breast carcinomas.
The p53 tumour-suppressor gene is important in the regulation of cell growth and apoptosis, and loss of functional wild-type activity may be associated with tumour formation and resistance to therapy. Differentiation of functionally normal wild-type protein from mutant or abnormal protein remains di...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1997
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2227991/ |