Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes

The permeability coefficients of a series of amides, ureas, and diols have been measured on red cells of man and dog using the minimum volume method of Sha'afi et al. When the molecules are grouped according to their ether-water partition coefficients, k ether, the behavior of the hydrophilic...

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Main Authors:	Sha'afi, R. I., Gary-Bobo, C. M., Solomon, A. K.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1971
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226026/

id	pubmed-2226026
recordtype	oai_dc
spelling	pubmed-22260262008-04-23 Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes Sha'afi, R. I. Gary-Bobo, C. M. Solomon, A. K. Article The permeability coefficients of a series of amides, ureas, and diols have been measured on red cells of man and dog using the minimum volume method of Sha'afi et al. When the molecules are grouped according to their ether-water partition coefficients, k ether, the behavior of the hydrophilic molecules, with k ether less than water, is different from that of the lipophilic molecules, characterized by k ether greater than water. The rate of permeation of the hydrophilic molecules through an aqueous pathway is determined by the molar volume, a parameter in which the geometrical measure of molecular volume is modified by hydrogen-bonding ability. This indicates the importance of chemical interactions within the aqueous path. The permeation of the lipophilic molecules is determined in the first instance by k ether, taken as a measure of the ease with which the molecule can escape from its aqueous environment. Within the membrane, lipophilic permeability is modified both by steric factors and by the formation of hydrogen bonds with membrane components. These data allow one to infer that lipid-soluble molecules travel through an organized structure within the lipid membrane and come into contact with polar moieties. The Rockefeller University Press 1971-09-01 /pmc/articles/PMC2226026/ /pubmed/5095677 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sha'afi, R. I. Gary-Bobo, C. M. Solomon, A. K.
spellingShingle	Sha'afi, R. I. Gary-Bobo, C. M. Solomon, A. K. Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
author_facet	Sha'afi, R. I. Gary-Bobo, C. M. Solomon, A. K.
author_sort	Sha'afi, R. I.
title	Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
title_short	Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
title_full	Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
title_fullStr	Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
title_full_unstemmed	Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes
title_sort	permeability of red cell membranes to small hydrophilic and lipophilic solutes
description	The permeability coefficients of a series of amides, ureas, and diols have been measured on red cells of man and dog using the minimum volume method of Sha'afi et al. When the molecules are grouped according to their ether-water partition coefficients, k ether, the behavior of the hydrophilic molecules, with k ether less than water, is different from that of the lipophilic molecules, characterized by k ether greater than water. The rate of permeation of the hydrophilic molecules through an aqueous pathway is determined by the molar volume, a parameter in which the geometrical measure of molecular volume is modified by hydrogen-bonding ability. This indicates the importance of chemical interactions within the aqueous path. The permeation of the lipophilic molecules is determined in the first instance by k ether, taken as a measure of the ease with which the molecule can escape from its aqueous environment. Within the membrane, lipophilic permeability is modified both by steric factors and by the formation of hydrogen bonds with membrane components. These data allow one to infer that lipid-soluble molecules travel through an organized structure within the lipid membrane and come into contact with polar moieties.
publisher	The Rockefeller University Press
publishDate	1971
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226026/
_version_	1611436942163968000

Permeability of Red Cell Membranes to Small Hydrophilic and Lipophilic Solutes

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