Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.

Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.

Photodynamic therapy is a method for treating cancer using drugs activated by light. A new compound, 5-aminolaevulinic acid (ALA), is a precursor of the active photosensitizer protoporphyrin IX (PpIX) and has fewer side-effects and much more transient phototoxicity than previous photosensitizers. Ce...

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Main Authors: Datta, S. N., Allman, R., Loh, C., Mason, M., Matthews, P. N.
Format: Online
Language:English
Published: Nature Publishing Group 1997
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224056/
id pubmed-2224056
recordtype oai_dc
spelling pubmed-22240562009-09-10 Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line. Datta, S. N. Allman, R. Loh, C. Mason, M. Matthews, P. N. Research Article Photodynamic therapy is a method for treating cancer using drugs activated by light. A new compound, 5-aminolaevulinic acid (ALA), is a precursor of the active photosensitizer protoporphyrin IX (PpIX) and has fewer side-effects and much more transient phototoxicity than previous photosensitizers. Cell survival of ALA-mediated photodynamic therapy was measured in the J82 bladder cancer cell line, along with its mitomycin C-resistant counterpart J82/MMC. This demonstrated that mitomycin resistance is not cross-resistant to photodynamic therapy. There was also a suggestion that the mitomycin-resistant cells were more susceptible to photodynamic therapy than the parent cell line. Photodynamic therapy appeared to enhance the effect of mitomycin C, when mitomycin C was given first. This phenomenon was apparent for both drug-resistant and drug-sensitive cell lines. This suggests a possible role for combined mitomycin C and photodynamic therapy in superficial bladder tumours that have recurred despite intravesical cytotoxic drug treatment. Nature Publishing Group 1997 /pmc/articles/PMC2224056/ /pubmed/9252197 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Datta, S. N.
Allman, R.
Loh, C.
Mason, M.
Matthews, P. N.
spellingShingle Datta, S. N.
Allman, R.
Loh, C.
Mason, M.
Matthews, P. N.
Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.
author_facet Datta, S. N.
Allman, R.
Loh, C.
Mason, M.
Matthews, P. N.
author_sort Datta, S. N.
title Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.
title_short Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.
title_full Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.
title_fullStr Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.
title_full_unstemmed Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line.
title_sort effect of photodynamic therapy in combination with mitomycin c on a mitomycin-resistant bladder cancer cell line.
description Photodynamic therapy is a method for treating cancer using drugs activated by light. A new compound, 5-aminolaevulinic acid (ALA), is a precursor of the active photosensitizer protoporphyrin IX (PpIX) and has fewer side-effects and much more transient phototoxicity than previous photosensitizers. Cell survival of ALA-mediated photodynamic therapy was measured in the J82 bladder cancer cell line, along with its mitomycin C-resistant counterpart J82/MMC. This demonstrated that mitomycin resistance is not cross-resistant to photodynamic therapy. There was also a suggestion that the mitomycin-resistant cells were more susceptible to photodynamic therapy than the parent cell line. Photodynamic therapy appeared to enhance the effect of mitomycin C, when mitomycin C was given first. This phenomenon was apparent for both drug-resistant and drug-sensitive cell lines. This suggests a possible role for combined mitomycin C and photodynamic therapy in superficial bladder tumours that have recurred despite intravesical cytotoxic drug treatment.
publisher Nature Publishing Group
publishDate 1997
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224056/
_version_ 1611436221236510720

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