GATA3-Driven Th2 Responses Inhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells

GATA3-Driven Th2 Responses Inhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells

Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical for polarization between Th1 and Th2 phenotypes. FOXP3 is an essential transcription factor for natural, thymus-derived...

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Bibliographic Details
Main Authors: Mantel, Pierre-Yves, Kuipers, Harmjan, Boyman, Onur, Rhyner, Claudio, Ouaked, Nadia, Rückert, Beate, Karagiannidis, Christian, Lambrecht, Bart N, Hendriks, Rudolf W, Crameri, Reto, Akdis, Cezmi A, Blaser, Kurt, Schmidt-Weber, Carsten B
Format: Online
Language:English
Published: Public Library of Science 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222968/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222968/

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