Gating Dynamics of the Acetylcholine Receptor Extracellular Domain

We used single-channel recording and model-based kinetic analyses to quantify the effects of mutations in the extracellular domain (ECD) of the α-subunit of mouse muscle–type acetylcholine receptors (AChRs). The crystal structure of an acetylcholine binding protein (AChBP) suggests that the ECD is c...

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Bibliographic Details
Main Authors: Chakrapani, Sudha, Bailey, Timothy D., Auerbach, Anthony
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217457/