Asymmetric and Independent Contribution of the Second Transmembrane Segment 12′ Residues to Diliganded Gating of Acetylcholine Receptor Channels: A Single-Channel Study with Choline as the Agonist
Mutagenesis studies have suggested that the second transmembrane segment (M2) plays a critical role during acetylcholine receptor liganded gating. An adequate description of the relationship between gating and structure of the M2 domain, however, has been hampered by the fact that many M2 mutations...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2000
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217223/ |