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pubmed-2215750
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| recordtype |
oai_dc
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| spelling |
pubmed-22157502008-04-23 The nonelectrolyte permeability of planar lipid bilayer membranes Articles The permeability of lecithin bilayer membranes to nonelectrolytes is in reasonable agreement with Overton's rule. The is, Pd alpha DKhc, where/Pd is the permeability coefficient of a solute through the bilayer, Khc is its hydrocarbon:water partition coefficient, and D is its diffusion coefficient in bulk hydrocarbon. The partition coefficients are by far the major determinants of the relative magnitudes of the permeability coefficients; the diffusion coefficients make only a minor contribution. We note that the recent emphasis on theoretically calculated intramembranous diffusion coefficients (Dm'S) has diverted attention from the experimentally measurable and physiologically relevant permeability coefficients (Pd'S) and has obscured the simplicity and usefulness of Overton's rule. The Rockefeller University Press 1980-04-01 /pmc/articles/PMC2215750/ /pubmed/7381427 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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| repository_type |
Open Access Journal
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| institution_category |
Foreign Institution
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| institution |
US National Center for Biotechnology Information
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| building |
NCBI PubMed
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| collection |
Online Access
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| language |
English
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| format |
Online
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| title |
The nonelectrolyte permeability of planar lipid bilayer membranes
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| spellingShingle |
The nonelectrolyte permeability of planar lipid bilayer membranes
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| title_short |
The nonelectrolyte permeability of planar lipid bilayer membranes
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| title_full |
The nonelectrolyte permeability of planar lipid bilayer membranes
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| title_fullStr |
The nonelectrolyte permeability of planar lipid bilayer membranes
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| title_full_unstemmed |
The nonelectrolyte permeability of planar lipid bilayer membranes
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| title_sort |
nonelectrolyte permeability of planar lipid bilayer membranes
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| description |
The permeability of lecithin bilayer membranes to nonelectrolytes is in reasonable agreement with Overton's rule. The is, Pd alpha DKhc, where/Pd is the permeability coefficient of a solute through the bilayer, Khc is its hydrocarbon:water partition coefficient, and D is its diffusion coefficient in bulk hydrocarbon. The partition coefficients are by far the major determinants of the relative magnitudes of the permeability coefficients; the diffusion coefficients make only a minor contribution. We note that the recent emphasis on theoretically calculated intramembranous diffusion coefficients (Dm'S) has diverted attention from the experimentally measurable and physiologically relevant permeability coefficients (Pd'S) and has obscured the simplicity and usefulness of Overton's rule.
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| publisher |
The Rockefeller University Press
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| publishDate |
1980
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| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215750/
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| _version_ |
1611435143139950592
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