Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery
Effects of adrenaline on the smooth muscle of the rabbit common carotid artery were studied by the partitional chamber method. The experiments on excitation-contraction coupling were carried out in isotonic Krebs solution; the other experiments were carried out in hypertonic Krebs solution. Adrenal...
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| Format: | Online |
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The Rockefeller University Press
1972
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213786/ |
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pubmed-22137862008-04-23 Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery Mekata, F. Niu, H. Article Effects of adrenaline on the smooth muscle of the rabbit common carotid artery were studied by the partitional chamber method. The experiments on excitation-contraction coupling were carried out in isotonic Krebs solution; the other experiments were carried out in hypertonic Krebs solution. Adrenaline (10-7 g/ml) caused rhythmical electrical and mechanical activity of arterial strips in isotonic Krebs solution. By addition of adrenaline (10-5 g/ml), the membrane was depolarized by about 10 mv and the amplitude of the electrotonic potential was decreased by 40–50% of the control in hypertonic Krebs solution. Present experimental results suggest that the depolarization of the membrane and the decrease of the amplitude of the electrotonic potential in the artery are due to the increase of Na and Cl conductance. Contraction appeared in all preparations exposed to 10-8 g/ml adrenaline; at that concentration membrane potential and membrane resistance showed little or no change. The Rockefeller University Press 1972-01-01 /pmc/articles/PMC2213786/ /pubmed/5007265 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mekata, F. Niu, H. |
| spellingShingle |
Mekata, F. Niu, H. Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery |
| author_facet |
Mekata, F. Niu, H. |
| author_sort |
Mekata, F. |
| title |
Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery |
| title_short |
Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery |
| title_full |
Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery |
| title_fullStr |
Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery |
| title_full_unstemmed |
Biophysical Effects of Adrenaline on the Smooth Muscle of the Rabbit Common Carotid Artery |
| title_sort |
biophysical effects of adrenaline on the smooth muscle of the rabbit common carotid artery |
| description |
Effects of adrenaline on the smooth muscle of the rabbit common carotid artery were studied by the partitional chamber method. The experiments on excitation-contraction coupling were carried out in isotonic Krebs solution; the other experiments were carried out in hypertonic Krebs solution. Adrenaline (10-7 g/ml) caused rhythmical electrical and mechanical activity of arterial strips in isotonic Krebs solution. By addition of adrenaline (10-5 g/ml), the membrane was depolarized by about 10 mv and the amplitude of the electrotonic potential was decreased by 40–50% of the control in hypertonic Krebs solution. Present experimental results suggest that the depolarization of the membrane and the decrease of the amplitude of the electrotonic potential in the artery are due to the increase of Na and Cl conductance. Contraction appeared in all preparations exposed to 10-8 g/ml adrenaline; at that concentration membrane potential and membrane resistance showed little or no change. |
| publisher |
The Rockefeller University Press |
| publishDate |
1972 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213786/ |
| _version_ |
1611434872870535168 |