Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

The germinal center (GC) is an anatomic compartment found in peripheral lymphoid organs, wherein B cells undergo clonal expansion, somatic mutation, switch recombination, and reactivate immunoglobulin gene V(D)J recombination. As a result of somatic mutation, some GC B cells develop higher affinity...

Full description

Bibliographic Details
Main Authors: Meffre, Eric, Papavasiliou, Fotini, Cohen, Paul, de Bouteiller, Odette, Bell, Diana, Karasuyama, Hajime, Schiff, Claudine, Banchereau, Jacques, Liu, Yong-Jun, Nussenzweig, Michel C.
Format: Online
Language:English
Published: The Rockefeller University Press 1998
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213359/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213359/

Similar Items