Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers Apoptosis in the Brain

Streptococcus pneumoniae is the most common cause of bacterial meningitis of high mortality and morbidity. Neurological sequelae include paralysis, mental retardation, and learning disorders. In humans, neurons of the hippocampus undergo apoptosis as a result of meningitis. Phosphatidylcholine (Ptd...

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Bibliographic Details
Main Authors: Zweigner, Janine, Jackowski, Suzanne, Smith, Shannon H., van der Merwe, Marie, Weber, Joerg R., Tuomanen, Elaine I.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213312/