Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

Engagement of the Fas receptor (CD95) initiates multiple signaling pathways that lead to apoptosis, such as the formation of death-inducing signaling complex (DISC), activation of caspase cascades, and the generation of the lipid messenger, ceramide. Sphingomyelin (SM) is a major component of lipid...

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Bibliographic Details
Main Authors: Miyaji, Michihiko, Jin, Zhe-Xiong, Yamaoka, Shohei, Amakawa, Ryuichi, Fukuhara, Shirou, Sato, Satoshi B., Kobayashi, Toshihide, Domae, Naochika, Mimori, Tsuneyo, Bloom, Eda T., Okazaki, Toshiro, Umehara, Hisanori
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213006/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213006/

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