CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo
Memory T cells, including the well-known CD4+ and CD8+ T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4+ and CD8+ T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a ra...
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| Format: | Online |
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The Rockefeller University Press
2005
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212999/ |
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pubmed-22129992008-03-11 CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo Cowley, Siobhán C. Hamilton, Elizabeth Frelinger, Jeffrey A. Su, Jie Forman, James Elkins, Karen L. Article Memory T cells, including the well-known CD4+ and CD8+ T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4+ and CD8+ T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a rare population of CD4−CD8−CD3+ αβ + γδ −NK1.1− T cells has similar functions. These cells potently and specifically inhibit the growth of the intracellular bacteria Mycobacterium tuberculosis (M. tb.) or Francisella tularensis Live Vaccine Strain (LVS) in macrophages in vitro, promote survival of mice infected with these organisms in vivo, and adoptively transfer immunity to F. tularensis LVS. Furthermore, these cells expand in the spleens of mice infected with M. tb. or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4−CD8− T cells have a role in the control of intracellular infection and may contribute to successful vaccination. The Rockefeller University Press 2005-07-18 /pmc/articles/PMC2212999/ /pubmed/16027239 http://dx.doi.org/10.1084/jem.20050569 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cowley, Siobhán C. Hamilton, Elizabeth Frelinger, Jeffrey A. Su, Jie Forman, James Elkins, Karen L. |
| spellingShingle |
Cowley, Siobhán C. Hamilton, Elizabeth Frelinger, Jeffrey A. Su, Jie Forman, James Elkins, Karen L. CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo |
| author_facet |
Cowley, Siobhán C. Hamilton, Elizabeth Frelinger, Jeffrey A. Su, Jie Forman, James Elkins, Karen L. |
| author_sort |
Cowley, Siobhán C. |
| title |
CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo |
| title_short |
CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo |
| title_full |
CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo |
| title_fullStr |
CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo |
| title_full_unstemmed |
CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo |
| title_sort |
cd4−cd8− t cells control intracellular bacterial infections both in vitro and in vivo |
| description |
Memory T cells, including the well-known CD4+ and CD8+ T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4+ and CD8+ T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a rare population of CD4−CD8−CD3+
αβ
+
γδ
−NK1.1− T cells has similar functions. These cells potently and specifically inhibit the growth of the intracellular bacteria Mycobacterium tuberculosis (M. tb.) or Francisella tularensis Live Vaccine Strain (LVS) in macrophages in vitro, promote survival of mice infected with these organisms in vivo, and adoptively transfer immunity to F. tularensis LVS. Furthermore, these cells expand in the spleens of mice infected with M. tb. or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4−CD8− T cells have a role in the control of intracellular infection and may contribute to successful vaccination. |
| publisher |
The Rockefeller University Press |
| publishDate |
2005 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212999/ |
| _version_ |
1611434498219573248 |