Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen
Transfer of naive antigen-specific CD4+ T cells into lymphopenic mice that express an endogenous antigen as a systemic, secreted protein results in severe autoimmunity resembling graft-versus-host disease. T cells that respond to this endogenous antigen develop into effector cells that cause the dis...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2005
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212975/ |