IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together

Traditionally, CD4+ T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called ThIL-17 has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether...

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Bibliographic Details
Main Authors: Bettelli, Estelle, Kuchroo, Vijay K.
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212800/