Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk

Inflammation can predispose to myocardial infarction (MI), and mannan binding lectin (MBL) promotes phagocytic clearance of inflammatory agents, but the predictive value of MBL levels for MI is not known. MBL was analyzed in subgroups of the population-based Reykjavik study, a cohort of 19,381 parti...

Full description

Bibliographic Details
Main Authors:	Saevarsdottir, Saedis, Oskarsson, Oskar Orn, Aspelund, Thor, Eiriksdottir, Gudny, Vikingsdottir, Thora, Gudnason, Vilmundur, Valdimarsson, Helgi
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2005
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212774/

id	pubmed-2212774
recordtype	oai_dc
spelling	pubmed-22127742008-03-11 Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk Saevarsdottir, Saedis Oskarsson, Oskar Orn Aspelund, Thor Eiriksdottir, Gudny Vikingsdottir, Thora Gudnason, Vilmundur Valdimarsson, Helgi Article Inflammation can predispose to myocardial infarction (MI), and mannan binding lectin (MBL) promotes phagocytic clearance of inflammatory agents, but the predictive value of MBL levels for MI is not known. MBL was analyzed in subgroups of the population-based Reykjavik study, a cohort of 19,381 participants recruited from 1967. MBL levels were very stable over time (self correlation: 0.86). In a cross-sectional group from the original cohort (n = 987), high MBL (>1,000 μg/L) was associated with a greatly lowered odds ratio for MI (0.64, P < 0.001). To verify this finding, a nested case control sample (n = 1,309) was randomly selected from the cohort. High MBL at recruitment was also associated with decreased MI risk in this follow-up group, but to a lesser extent and not significant for the whole group, smokers, or hypertensive individuals. However, high MBL was as in the cross-sectional group, associated with greatly decreased MI risk in diabetic (P = 0.02) or hypercholesterolemic individuals (P = 0.004). This also applied to raised erythrocyte sedimentation rate (P = 0.007). Diabetic patients with high MBL did not have a higher MI risk than nondiabetic individuals. Our findings indicate that high MBL may predict decreased likelihood of MI, particularly in diabetics, and are consistent with the possibility that MBL may promote clearance of atherogenic agents. The Rockefeller University Press 2005-01-03 /pmc/articles/PMC2212774/ /pubmed/15623574 http://dx.doi.org/10.1084/jem.20041431 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Saevarsdottir, Saedis Oskarsson, Oskar Orn Aspelund, Thor Eiriksdottir, Gudny Vikingsdottir, Thora Gudnason, Vilmundur Valdimarsson, Helgi
spellingShingle	Saevarsdottir, Saedis Oskarsson, Oskar Orn Aspelund, Thor Eiriksdottir, Gudny Vikingsdottir, Thora Gudnason, Vilmundur Valdimarsson, Helgi Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
author_facet	Saevarsdottir, Saedis Oskarsson, Oskar Orn Aspelund, Thor Eiriksdottir, Gudny Vikingsdottir, Thora Gudnason, Vilmundur Valdimarsson, Helgi
author_sort	Saevarsdottir, Saedis
title	Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
title_short	Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
title_full	Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
title_fullStr	Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
title_full_unstemmed	Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
title_sort	mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
description	Inflammation can predispose to myocardial infarction (MI), and mannan binding lectin (MBL) promotes phagocytic clearance of inflammatory agents, but the predictive value of MBL levels for MI is not known. MBL was analyzed in subgroups of the population-based Reykjavik study, a cohort of 19,381 participants recruited from 1967. MBL levels were very stable over time (self correlation: 0.86). In a cross-sectional group from the original cohort (n = 987), high MBL (>1,000 μg/L) was associated with a greatly lowered odds ratio for MI (0.64, P < 0.001). To verify this finding, a nested case control sample (n = 1,309) was randomly selected from the cohort. High MBL at recruitment was also associated with decreased MI risk in this follow-up group, but to a lesser extent and not significant for the whole group, smokers, or hypertensive individuals. However, high MBL was as in the cross-sectional group, associated with greatly decreased MI risk in diabetic (P = 0.02) or hypercholesterolemic individuals (P = 0.004). This also applied to raised erythrocyte sedimentation rate (P = 0.007). Diabetic patients with high MBL did not have a higher MI risk than nondiabetic individuals. Our findings indicate that high MBL may predict decreased likelihood of MI, particularly in diabetics, and are consistent with the possibility that MBL may promote clearance of atherogenic agents.
publisher	The Rockefeller University Press
publishDate	2005
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212774/
_version_	1611434366836146176

Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk

Similar Items