Senescent Impairment in Synergistic Cytokine Pathways That Provide Rapid Cardioprotection in the Rat Heart

Pretreatment of rodent hearts with platelet-derived growth factor (PDGF)–AB decreases myocardial injury after coronary occlusion. However, PDGF-AB cardioprotection is diminished in older animals, suggesting that downstream elements mediating and/or synergizing the actions of PDGF-AB may be limited i...

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Bibliographic Details
Main Authors: Xaymardan, Munira, Zheng, Jingang, Duignan, Inga, Chin, Andrew, Holm, Jacquelyne M., Ballard, Victoria L.T., Edelberg, Jay M.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212728/