IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from peripheral blood mononuclear cells (PBMC). Furthermore, in vivo blockade of endogenous IL-23 activity by treatment with anti-IL-23 antibody attenuates collagen-induced arthritis in rats by preventing both inf...

Full description

Bibliographic Details
Main Authors: Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Furuya, Takefumi, Kobashigawa, Tsuyoshi, Kamatani, Naoyuki, Kotake, Shigeru
Format: Online
Language:English
Published: BioMed Central 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212562/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212562/

Similar Items