Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

Two novel synthetic tetrapeptides, VEID-CHO and DMQD-CHO, could selectively inhibit caspase-6 and caspase-3, respectively. We used these inhibitors to dissect the pathway of caspase activation in Fas-stimulated Jurkat cells and identify the roles of each active caspase in apoptotic processes. Affini...

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Bibliographic Details
Main Authors: Hirata, Hirokazu, Takahashi, Atsushi, Kobayashi, Susumu, Yonehara, Shin, Sawai, Hirofumi, Okazaki, Toshiro, Yamamoto, Kokichi, Sasada, Masataka
Format: Online
Language:English
Published: The Rockefeller University Press 1998
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212161/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212161/

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