Anthrolysin O and Other Gram-positive Cytolysins Are Toll-like Receptor 4 Agonists

Anthrolysin O and Other Gram-positive Cytolysins Are Toll-like Receptor 4 Agonists

Exposure of bone marrow–derived macrophages (BMDMs) to low concentrations of Bacillus anthracis lethal toxin (LT), whose catalytic subunit is lethal factor (LF), results in induction of a robust apoptotic response dependent on activation of Toll-like receptor (TLR)4. A similar TLR4-dependent apoptot...

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Bibliographic Details
Main Authors: Park, Jin Mo, Ng, Vincent H., Maeda, Shin, Rest, Richard F., Karin, Michael
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211988/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211988/

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