Deletion of the Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching and Alters Mutations Near Switch Recombination Junctions

Deletion of the Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching and Alters Mutations Near Switch Recombination Junctions

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway. ERCC1-XPF nicks double-stranded DNA immediately adjacent to 3′ single-strand regions. Substrates include DNA bubbles and flaps. Furthermore, ERCC1 interacts with Msh2, a mismatch re...

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Bibliographic Details
Main Authors: Schrader, Carol E., Vardo, Joycelyn, Linehan, Erin, Twarog, Michael Z., Niedernhofer, Laura J., Hoeijmakers, Jan H.J., Stavnezer, Janet
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211985/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211985/

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