Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl

Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl

Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms. B lymphomas occurring in Fasl mutant (gld) mice usually are immunoglobulin (Ig) isotype switched, secrete Ig, and are plasmacytoid in appearance...

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Main Authors: Zhang, Jian Qiao, Okumura, Cheryl, McCarty, Thomas, Shin, Min Sun, Mukhopadhyay, Partha, Hori, Mitsuo, Torrey, Ted A., Naghashfar, Zohreh, Zhou, Jeff X., Lee, Chang Hoon, Roopenian, Derry C., Morse, Herbert C., Davidson, Wendy F.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211944/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211944/

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