The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media

This paper presents evidence that duck erythrocytes regulate their size in isotonic media by utilizing a previously reported "volume-controlling mechanism." Two different experimental situations are examined. In the first, cells enlarge in a solution containing norepinephrine and an eleva...

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Main Author:	Kregenow, Floyd M.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1973
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203477/

id	pubmed-2203477
recordtype	oai_dc
spelling	pubmed-22034772008-04-23 The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media Kregenow, Floyd M. Article This paper presents evidence that duck erythrocytes regulate their size in isotonic media by utilizing a previously reported "volume-controlling mechanism." Two different experimental situations are examined. In the first, cells enlarge in a solution containing norepinephrine and an elevated [K]o; and in the second, enlarged cells shrink to their original size if the norepinephrine and excess potassium are removed. As the erythrocytes enlarge, K, Cl, and H2O accumulate. Shrinkage, in contrast, is accompanied by the controlled loss of K, Cl, and H2O. These changes and the associated changes in membrane permeability resemble those reported previously when duck erythrocytes incubate in anisotonic media. There cells, after first shrinking or swelling, utilize a "volume-controlling mechanism" to reestablish their original size. The mechanism regulates cell size by adjusting the total number of osmotically active intracellular particles. The present studies indicate duck red cells use this mechanism to readjust their total monovalent cation content and thus their solute content in isotonic media as well. In addition, evidence is presented which indicates that the "volume-controlling mechanism" and ouabain-inhibitable cation pump differ functionally. The Rockefeller University Press 1973-04-01 /pmc/articles/PMC2203477/ /pubmed/4694744 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kregenow, Floyd M.
spellingShingle	Kregenow, Floyd M. The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media
author_facet	Kregenow, Floyd M.
author_sort	Kregenow, Floyd M.
title	The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media
title_short	The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media
title_full	The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media
title_fullStr	The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media
title_full_unstemmed	The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media
title_sort	reponse of duck erythrocytes to norepinephrine and an elevated extracellular potassium : volume regulation in isotonic media
description	This paper presents evidence that duck erythrocytes regulate their size in isotonic media by utilizing a previously reported "volume-controlling mechanism." Two different experimental situations are examined. In the first, cells enlarge in a solution containing norepinephrine and an elevated [K]o; and in the second, enlarged cells shrink to their original size if the norepinephrine and excess potassium are removed. As the erythrocytes enlarge, K, Cl, and H2O accumulate. Shrinkage, in contrast, is accompanied by the controlled loss of K, Cl, and H2O. These changes and the associated changes in membrane permeability resemble those reported previously when duck erythrocytes incubate in anisotonic media. There cells, after first shrinking or swelling, utilize a "volume-controlling mechanism" to reestablish their original size. The mechanism regulates cell size by adjusting the total number of osmotically active intracellular particles. The present studies indicate duck red cells use this mechanism to readjust their total monovalent cation content and thus their solute content in isotonic media as well. In addition, evidence is presented which indicates that the "volume-controlling mechanism" and ouabain-inhibitable cation pump differ functionally.
publisher	The Rockefeller University Press
publishDate	1973
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203477/
_version_	1611433431442391040

The Reponse of Duck Erythrocytes to Norepinephrine and an Elevated Extracellular Potassium : Volume regulation in isotonic media

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