The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1

The frog urinary bladder undergoes, in some conditions, a marked increase of its water permeability when incubated in hypertonic media. This increase was observed with various nonpermeant solutes. It seems to result from the shrinkage of an osmo-sensitive compartment of the tissue, probably the epi...

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Main Authors:	Ripoche, P., Bourguet, J., Parisi, M.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1973
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203462/

id	pubmed-2203462
recordtype	oai_dc
spelling	pubmed-22034622008-04-23 The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1 Ripoche, P. Bourguet, J. Parisi, M. Article The frog urinary bladder undergoes, in some conditions, a marked increase of its water permeability when incubated in hypertonic media. This increase was observed with various nonpermeant solutes. It seems to result from the shrinkage of an osmo-sensitive compartment of the tissue, probably the epithelial cells. Many similarities were found between this effect and the physiological increase in water permeability (hydrosmotic response) elicited by antidiuretic hormone (ADH): both were dependent on the physiological state of the animals, and although the response was slower after hyperosmolar than after hormonal challenge, the patterns of response were similar, and in both cases markedly dependent on bathing solution temperature. Norepinephrine and prostaglandin E1, which in this tissue reduce the hydrosmotic action of ADH, presumably by inhibiting the adenyl cylase also reduced the effect of hyperosmolarity. Conversely this effect was potentiated by incubation in the presence of oxytocin, exogenous cyclic AMP, and theophylline, conditions in which the intracellular concentration of cyclic AMP is increased. These data demonstrate that the response to hyperosmolarity is elicited, at least partly, by mechanisms also involved in the physiological hydrosmotic response to ADH. The Rockefeller University Press 1973-01-01 /pmc/articles/PMC2203462/ /pubmed/4345637 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ripoche, P. Bourguet, J. Parisi, M.
spellingShingle	Ripoche, P. Bourguet, J. Parisi, M. The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1
author_facet	Ripoche, P. Bourguet, J. Parisi, M.
author_sort	Ripoche, P.
title	The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1
title_short	The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1
title_full	The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1
title_fullStr	The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1
title_full_unstemmed	The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1
title_sort	effect of hypertonic media on water permeability of frog urinary bladder : inhibition by catecholamines and prostaglandin e1
description	The frog urinary bladder undergoes, in some conditions, a marked increase of its water permeability when incubated in hypertonic media. This increase was observed with various nonpermeant solutes. It seems to result from the shrinkage of an osmo-sensitive compartment of the tissue, probably the epithelial cells. Many similarities were found between this effect and the physiological increase in water permeability (hydrosmotic response) elicited by antidiuretic hormone (ADH): both were dependent on the physiological state of the animals, and although the response was slower after hyperosmolar than after hormonal challenge, the patterns of response were similar, and in both cases markedly dependent on bathing solution temperature. Norepinephrine and prostaglandin E1, which in this tissue reduce the hydrosmotic action of ADH, presumably by inhibiting the adenyl cylase also reduced the effect of hyperosmolarity. Conversely this effect was potentiated by incubation in the presence of oxytocin, exogenous cyclic AMP, and theophylline, conditions in which the intracellular concentration of cyclic AMP is increased. These data demonstrate that the response to hyperosmolarity is elicited, at least partly, by mechanisms also involved in the physiological hydrosmotic response to ADH.
publisher	The Rockefeller University Press
publishDate	1973
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203462/
_version_	1611433421562707968

The Effect of Hypertonic Media on Water Permeability of Frog Urinary Bladder : Inhibition by catecholamines and prostaglandin E1

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