Ammonium Ion Currents in the Squid Giant Axon
Voltage-clamp studies on intact and internally perfused squid giant axons demonstrate that ammonium can substitute partially for either sodium or potassium. Ammonium carries the early transient current with 0.3 times the permeability of sodium and it carries the delayed current with 0.3 times the p...
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| Format: | Online |
| Language: | English |
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The Rockefeller University Press
1969
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202909/ |
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pubmed-2202909 |
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pubmed-22029092008-04-23 Ammonium Ion Currents in the Squid Giant Axon Binstock, Leonard Lecar, Harold Article Voltage-clamp studies on intact and internally perfused squid giant axons demonstrate that ammonium can substitute partially for either sodium or potassium. Ammonium carries the early transient current with 0.3 times the permeability of sodium and it carries the delayed current with 0.3 times the potassium permeability. The conductance changes observed in voltage clamp show approximately the same time course in ammonium solutions as in the normal physiological solutions. These ammonium ion permeabilities account for the known effects of ammonium on nerve excitability. Experiments with the drugs tetrodotoxin (TTX) and tetraethyl ammonium chloride (TEA) demonstrate that these molecules block the early and late components of the current selectively, even when both components are carried by the same ion, ammonium. The Rockefeller University Press 1969-03-01 /pmc/articles/PMC2202909/ /pubmed/5767336 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Binstock, Leonard Lecar, Harold |
| spellingShingle |
Binstock, Leonard Lecar, Harold Ammonium Ion Currents in the Squid Giant Axon |
| author_facet |
Binstock, Leonard Lecar, Harold |
| author_sort |
Binstock, Leonard |
| title |
Ammonium Ion Currents in the Squid Giant Axon |
| title_short |
Ammonium Ion Currents in the Squid Giant Axon |
| title_full |
Ammonium Ion Currents in the Squid Giant Axon |
| title_fullStr |
Ammonium Ion Currents in the Squid Giant Axon |
| title_full_unstemmed |
Ammonium Ion Currents in the Squid Giant Axon |
| title_sort |
ammonium ion currents in the squid giant axon |
| description |
Voltage-clamp studies on intact and internally perfused squid giant axons demonstrate that ammonium can substitute partially for either sodium or potassium. Ammonium carries the early transient current with 0.3 times the permeability of sodium and it carries the delayed current with 0.3 times the potassium permeability. The conductance changes observed in voltage clamp show approximately the same time course in ammonium solutions as in the normal physiological solutions. These ammonium ion permeabilities account for the known effects of ammonium on nerve excitability. Experiments with the drugs tetrodotoxin (TTX) and tetraethyl ammonium chloride (TEA) demonstrate that these molecules block the early and late components of the current selectively, even when both components are carried by the same ion, ammonium. |
| publisher |
The Rockefeller University Press |
| publishDate |
1969 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202909/ |
| _version_ |
1611433329960157184 |