CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

Self-antigens expressed in extrathymic tissues such as the pancreas can be transported to draining lymph nodes and presented in a class I–restricted manner by bone marrow-derived antigen-presenting cells. Such cross-presentation of self-antigens leads to CD8+ T cell tolerance induction via deletion....

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Bibliographic Details
Main Authors: Kurts, Christian, Carbone, Francis R., Barnden, Megan, Blanas, Effrossini, Allison, Janette, Heath, William R., Miller, Jacques F.A.P.
Format: Online
Language:English
Published: The Rockefeller University Press 1997
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199175/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199175/

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