A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cell– tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is used by macrophage (M)-tropic strains. Here we show that a small-molecule inhibitor, ALX40-4C, inhibits HIV-1 envelope (Env)-mediated membrane...

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Bibliographic Details
Main Authors: Doranz, Benjamin J., Grovit-Ferbas, Kathie, Sharron, Matthew P., Mao, Si-Hua, Goetz, Matthew Bidwell, Daar, Eric S., Doms, Robert W., O'Brien, William A.
Format: Online
Language:English
Published: The Rockefeller University Press 1997
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199097/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199097/

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