Inhibition of Virus Attachment to CD4+ Target Cells Is a Major Mechanism of T Cell Line–adapted HIV-1 Neutralization

Antibody-mediated neutralization of human immunodeficiency virus type–1 (HIV-1) is thought to function by at least two distinct mechanisms: inhibition of virus–receptor binding, and interference with events after binding, such as virus–cell membrane fusion. Here we show, by the use of a novel virus–...

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Bibliographic Details
Main Authors: Ugolini, Sophie, Mondor, Isabelle, Parren, Paul W.H.I., Burton, Dennis R., Tilley, Shermaine A., Klasse, Per Johan, Sattentau, Quentin J.
Format: Online
Language:English
Published: The Rockefeller University Press 1997
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199094/