A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells

Tumor necrosis factor receptor (TNFR)–associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 work...

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Main Authors:	Speiser, Daniel E., Lee, Soo Young, Wong, Brian, Arron, Joseph, Santana, Angela, Kong, Young-Yun, Ohashi, Pamela S., Choi, Yongwon
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1997
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196328/

id	pubmed-2196328
recordtype	oai_dc
spelling	pubmed-21963282008-04-16 A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells Speiser, Daniel E. Lee, Soo Young Wong, Brian Arron, Joseph Santana, Angela Kong, Young-Yun Ohashi, Pamela S. Choi, Yongwon Article Tumor necrosis factor receptor (TNFR)–associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 works as a mediator for activation signals such as NF-κB, but the role of TRAF1 has not been previously determined. Here we show in transgenic mice that TRAF1 overexpression inhibits antigen-induced apoptosis of CD8+ T lymphocytes. Our results demonstrate a biological role for TRAF1 as a regulator of apoptotic signals and also support the hypothesis that the combination of TRAF proteins in a given cell type determines distinct biological effects triggered by members of the TNF receptor superfamily. The Rockefeller University Press 1997-05-19 /pmc/articles/PMC2196328/ /pubmed/9151703 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Speiser, Daniel E. Lee, Soo Young Wong, Brian Arron, Joseph Santana, Angela Kong, Young-Yun Ohashi, Pamela S. Choi, Yongwon
spellingShingle	Speiser, Daniel E. Lee, Soo Young Wong, Brian Arron, Joseph Santana, Angela Kong, Young-Yun Ohashi, Pamela S. Choi, Yongwon A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
author_facet	Speiser, Daniel E. Lee, Soo Young Wong, Brian Arron, Joseph Santana, Angela Kong, Young-Yun Ohashi, Pamela S. Choi, Yongwon
author_sort	Speiser, Daniel E.
title	A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
title_short	A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
title_full	A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
title_fullStr	A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
title_full_unstemmed	A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
title_sort	regulatory role for traf1 in antigen-induced apoptosis of t cells
description	Tumor necrosis factor receptor (TNFR)–associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 works as a mediator for activation signals such as NF-κB, but the role of TRAF1 has not been previously determined. Here we show in transgenic mice that TRAF1 overexpression inhibits antigen-induced apoptosis of CD8+ T lymphocytes. Our results demonstrate a biological role for TRAF1 as a regulator of apoptotic signals and also support the hypothesis that the combination of TRAF proteins in a given cell type determines distinct biological effects triggered by members of the TNF receptor superfamily.
publisher	The Rockefeller University Press
publishDate	1997
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196328/
_version_	1611432549479874560

A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells

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