Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells
Jak3 mediates growth signals through cytokine receptors such as interleukin-2 (IL-2), IL-4, and IL-7, and its deficiency results in autosomal recessive SCID in mice and humans. In spite of the severely reduced number of lymphocytes in Jak3-deficient mice, the differentiation profile of thymocytes wa...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
1997
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196119/ |