Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-specific Killer T Cells by Dendritic Cells
The mechanism of antitumor effect of monoclonal antibodies (mAbs) is not fully understood. Here we show that coating myeloma cells with anti–syndecan-1 antibody promotes cross-presentation of cellular antigens by dendritic cells (DCs) to autologous T cells from healthy donors. The tumor cells treate...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2002
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196013/ |