ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR

ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR

Frog sartorius muscles, equilibrated to 2 x 10-4 M iodoacetic acid-Ringer's solution and activated by a series of twitches or a long tetanus, perform a rigor response consisting in general of a contractile change which plateaus and is then automatically reversed. Isotonic rigor shortening obey...

Full description

Bibliographic Details
Main Authors: Mauriello, George E., Sandow, Alexander
Format: Online
Language:English
Published: The Rockefeller University Press 1959
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194947/
id pubmed-2194947
recordtype oai_dc
spelling pubmed-21949472008-04-23 ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR Mauriello, George E. Sandow, Alexander Article Frog sartorius muscles, equilibrated to 2 x 10-4 M iodoacetic acid-Ringer's solution and activated by a series of twitches or a long tetanus, perform a rigor response consisting in general of a contractile change which plateaus and is then automatically reversed. Isotonic rigor shortening obeys a force-velocity relation which, with certain differences in value of the constants, accords with Hill's equation for this relation. Changes in rigidity during either isotonic or isometric rigor response show that the capacity of the rigor muscle to bear a load increases more abruptly than the corresponding onset of the ordinarily recorded response, briefly plateaus, and then decays. A quick release of about 1 mm. applied at any instant of isometric rigor output causes the tension to drop instantaneously to zero and then redevelop, the rate of redevelopment varying as does the intensity of the load-bearing capacity. These results demonstrate that rigor mechanical responses result from interaction of a passive, undamped series elastic component, and a contractile component with active state properties like those of normal contraction. Adenosinetriphosphate is known to break down in association with development of the rigor active state. This is discussed in relation to the apparent absence of ATP splitting in normal activation of the contractile component. The Rockefeller University Press 1959-05-20 /pmc/articles/PMC2194947/ /pubmed/13654738 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Mauriello, George E.
Sandow, Alexander
spellingShingle Mauriello, George E.
Sandow, Alexander
ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR
author_facet Mauriello, George E.
Sandow, Alexander
author_sort Mauriello, George E.
title ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR
title_short ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR
title_full ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR
title_fullStr ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR
title_full_unstemmed ACTIVE STATE OF MUSCLE IN IODOACETATE RIGOR
title_sort active state of muscle in iodoacetate rigor
description Frog sartorius muscles, equilibrated to 2 x 10-4 M iodoacetic acid-Ringer's solution and activated by a series of twitches or a long tetanus, perform a rigor response consisting in general of a contractile change which plateaus and is then automatically reversed. Isotonic rigor shortening obeys a force-velocity relation which, with certain differences in value of the constants, accords with Hill's equation for this relation. Changes in rigidity during either isotonic or isometric rigor response show that the capacity of the rigor muscle to bear a load increases more abruptly than the corresponding onset of the ordinarily recorded response, briefly plateaus, and then decays. A quick release of about 1 mm. applied at any instant of isometric rigor output causes the tension to drop instantaneously to zero and then redevelop, the rate of redevelopment varying as does the intensity of the load-bearing capacity. These results demonstrate that rigor mechanical responses result from interaction of a passive, undamped series elastic component, and a contractile component with active state properties like those of normal contraction. Adenosinetriphosphate is known to break down in association with development of the rigor active state. This is discussed in relation to the apparent absence of ATP splitting in normal activation of the contractile component.
publisher The Rockefeller University Press
publishDate 1959
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194947/
_version_ 1611431754269196288

Similar Items