DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become sus...

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Main Authors:	Tassaneetrithep, Boonrat, Burgess, Timothy H., Granelli-Piperno, Angela, Trumpfheller, Christine, Finke, Jennifer, Sun, Wellington, Eller, Michael A., Pattanapanyasat, Kovit, Sarasombath, Suttipant, Birx, Deborah L., Steinman, Ralph M., Schlesinger, Sarah, Marovich, Mary A.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2003
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/

id	pubmed-2193896
recordtype	oai_dc
spelling	pubmed-21938962008-04-11 DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. Article Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection. The Rockefeller University Press 2003-04-07 /pmc/articles/PMC2193896/ /pubmed/12682107 http://dx.doi.org/10.1084/jem.20021840 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A.
spellingShingle	Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
author_facet	Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A.
author_sort	Tassaneetrithep, Boonrat
title	DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_short	DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_full	DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_fullStr	DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_full_unstemmed	DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_sort	dc-sign (cd209) mediates dengue virus infection of human dendritic cells
description	Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.
publisher	The Rockefeller University Press
publishDate	2003
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/
_version_	1611431367313195008

DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

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